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David Hall

Lawrence University
Understanding the mechanisms of rhinovirus-induced inflammation
The long-range goal of our research program is to understand the mechanisms by which rhinovirus activation of macrophages leads to the exacerbation of asthma. Previous studies have implicated the macrophage as playing an important role in the elaboration of the inflammatory environment observed in exacerbation of asthma. However, the details of the role of macrophages in virus-mediated cytokine release, the signaling pathways and mechanisms that promote the release of cytokines during rhinovirus infection and asthma exacerbations are still very poorly understood. Over the last 6 years, our research program has established that there is a specific inflammatory response to different rhinovirus serotypes. This specific response is the result of differential activation of the mitogen activated protein kinase (MAPK) pathways. Furthermore, we have determined that interleukin-10, gamma-amino butyric acid (GABA), immunoglobulin G and 2-arachidonoylglycerol play an important role in the virus specific inflammatory response.
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