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John Russell

Washington University in St. Louis
Microbiology, Biology
Apoptosis (Cell Death) in health and disease
The last decade has seen a shifting paradigm in the regulation of tissue homeostasis and development. It is now clear that regulated programs of cell death (apoptosis) are as important as regulation of cellular proliferation. Controlled cell death is essential in morphogenesis in all multicellular organisms as well as the maintenance of homeostasis of adult tissues. Apoptotic mechanisms are also important both in protection from viral infection as well as mechanisms of pathogenesis in autoimmune disease. Subversion of these apoptotic regulatory mechanisms is also important the selection and maintenance of neoplasia.
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