Connecting campuses to promote excellence in math and science


Erik Herzog

Washington University in St. Louis
Circadian timekeeping in the mammalian brain
This lecture will address recent discoveries in biological timing. Clocks that keep near-perfect daily time have been localized to single cells in the brain and body. I will highlight the genes, molecules, cells and systems which coordinately work to wake us each morning and to regulate alertness while we work. Advances in cellular physiology allow us to watch these clocks tick in the animal and in a dish. The results suggest that normal homeostasis often means oscillation and that modern lifestyles often disrupt these natural daily cycles.
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